Originally known as Moss Lane, then Great Brunswick Street after the reigning house of Hanover, and later Pearse Street after Padraig and Willie Pearse, leaders of the 1916 Easter Rising who were born here.
| Year | Architect | Building |
| 1729-57 | - | St. Mark's Church |
| 1820 | - | No. 27 |
| 1824 | - | Former Academy Cinema |
| 1825 | - | Nos. 183-186 |
| 1835 | - | No. 201 Nuzum Bros |
| 1839-70 | - | Pearse Square |
| 1862 | Alfred Darbyshire | Enterprise Centre |
| 1885 | - | O'Neill's Public House |
| 1895-97 | William Hague | Former St. Andrew's National Schools |
| 1905-06 | C.J. McCarthy | Former Fire Station |
| 1907-09 | C.J. McCarthy | Gilbert Library |
| 1915 | A. Robinson, M.J. Burke, H.G. Leask | Garda Station |
| 1972 | Tyndall Hogan Hurley | Oisin House |
| 1996 | Moloney O'Beirne Architects | Aras an Phiarsaigh |
| 2003 | - | Goldsmith House |